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Italian Penicillin Soup: Step-by-Step Instructions

★★★★★4.5 (20 reviews)

Healthier Alternatives for Italian Penicillin Soup

One of the most common questions I get is, “Can I make a healthier version of this healthy chicken soup?” Absolutely! This soup is wonderfully adaptable.


For a lighter broth, you can use low-sodium chicken broth and control the salt yourself. You can also swap the chicken thighs for lean chicken breast, though thighs do give a richer flavor. To boost the veggie content, toss in a handful of spinach or kale during the last few minutes of cooking.

How to Serve Italian Penicillin Soup

In our house, serving this soup is a ritual. We pile into the cozy corner of the kitchen, wrap our hands around warm bowls, and let the steam work its magic. It’s the ultimate quick chicken soup for a weary soul.


I love to serve it with a side of crusty, buttered bread for dipping and a simple green salad. A light, crisp Pinot Grigio pairs nicely for the adults, but a simple cup of tea is just as perfect. It’s all about the comfort.

Frequently Asked Questions

What exactly is Italian Penicillin Soup and why is it called that?

Italian Penicillin Soup is a hearty, brothy chicken soup packed with vegetables, herbs, and pasta. It’s affectionately called “penicillin” because of its legendary reputation for healing and providing comfort when you’re under the weather, much like the medicine.

How does Italian Penicillin Soup help when you’re feeling sick?

The warm broth helps keep you hydrated and soothes a sore throat. The steam can clear sinuses, and the combination of nutrients from the chicken and vegetables provides easy-to-digest nourishment that gives your body energy to heal.

What are the key ingredients in an authentic Italian Penicillin Soup?

The soul of this soup is a rich chicken broth, tender chicken, the classic trio of onion, carrots, and celery (soffritto), healing garlic and herbs like oregano and thyme, and a small pasta like ditalini.

Can I make Italian Penicillin Soup in a slow cooker or Instant Pot?

You certainly can! For a slow cooker, sauté the veggies first, then add everything except the pasta and cook on low for 6-7 hours. For an Instant Pot, use the sauté function for the veggies, then pressure cook for 10 minutes. Add the pasta after and use the sauté function to cook it through.

What’s the difference between Italian Penicillin Soup and regular chicken soup?

While both are comforting, Italian Penicillin Soup typically includes specific Italian herbs like oregano and often features a small pasta, giving it a heartier, more robust character compared to a simpler American-style chicken noodle soup.

What kind of pasta is traditionally used in Italian Penicillin Soup?

Small pasta shapes are traditional because they are easy to eat and fit perfectly on a spoon. Ditalini is the classic choice, but orzo, pastina, or even small shells work beautifully.

Can you make a vegetarian version of Italian Penicillin Soup?

Yes! Simply use a rich vegetable broth and omit the chicken. You can add white beans or chickpeas for protein and keep all the wonderful herbs and vegetables for a truly healing and delicious vegetarian meal.

🛒 Tools we love: Cutting board, Tongs, Slow cooker. As an Amazon Associate, I earn from qualifying purchases.

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Comments (20)

B
BakingBeth R.10 months ago
★★★★★
So easy and foolproof — thank you! Used what I had on hand (a sugar substitute) and it was still perfect.
M
Michael10 months ago
★★★★★
Swapped in fresh fruit to make it a bit lighter.
J
Jessica J.9 months ago
★★★★
This is going straight into our regular rotation. Would this work with low-fat milk?
K
Karen9 months ago
★★★★★
My new favorite. Thanks for sharing! Can I use frozen berries instead of butter?
A
All Muffins Author
It keeps about about 5 days in the fridge in an airtight container.
T
thehungrynurse9 months ago
★★★★★
Honestly one of the best versions I've made.
A
All Muffins Author
Thank you! That little tweak sounds great.
J
James8 months ago
★★★
Swapped in coconut sugar to make it a bit lighter.
M
Mark M.7 months ago
★★★★
Can I use coconut sugar instead of sugar?
G
GrillMasterJ H.7 months ago
★★★★★
So easy and rich and satisfying — thank you!
M
MamaBear227 months ago
★★★★
Just tried this and it was so good. I used coconut sugar instead and it still worked great.
B
BrunchBuddy F.7 months ago
★★★★★
Just tried this and it was perfect. What could I use in place of sugar?
B
Barbara G.6 months ago
★★★★★
Made this for meal prep — restaurant-quality! What could I use in place of sugar?
S
Sarah G.5 months ago
★★★
Could I make this ahead for a party?
K
Kevin J.4 months ago
★★★★★
Followed the recipe exactly and it came out absolutely delicious. I used almond milk instead and it still worked great.
A
All Muffins Author
That means a lot, thank you! Enjoy.
B
Ben D.4 months ago
★★★★★
Huge hit — my wife devoured it. Swapped in fresh fruit to make it a bit lighter.
O
Omar3 months ago
★★★★★
Would this work with low-fat milk?
S
Steve3 months ago
★★★★★
Made this for meal prep — foolproof! How long does this keep in the fridge?
A
All Muffins Author
It keeps about about 5 days in the fridge in an airtight container.
M
Megan F.3 months ago
★★★
Simple ingredients, foolproof results. Cut the white sugar down a bit and loved it.
L
Liam R.3 months ago
★★★★★
Saved this one for sure. Came out light and refreshing. How long does this keep in the fridge?
H
HealthyEats N.2 months ago
★★★★★
Made this for dinner — rich and satisfying! Do you think I could freeze the leftovers?
A
Andre C.6 weeks ago
★★★★★
So easy and amazing — thank you! Used what I had on hand (fresh fruit) and it was still absolutely delicious.

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